化合物Alphitolic acid TN1379

Product Introduction
Bioactivity


英文名: Alphitolic acid

描述: Alphitolic acid is a potent Hh/GLI signaling inhibitor, it shows an important relationship between Hh/GLI signaling inhibition, the decrease of BCL2, and cytotoxicity against cancer cells.

体外活性: The phytochemical investigation of the triterpenic fraction yielded nine triterpenic acids, ceanothic acid (1), Alphitolic acid (2), maslinic acid (3), 3- O-cis-coumaroyl Alphitolic acid (4), 3- O-trans-coumaroyl Alphitolic acid (5), 3- O-trans-coumaroyl maslinic acid (6), 3- O-cis-coumaroyl maslinic acid (7), betulinic acid (8), and oleanolic acid (9). In order to perform the quantitative determination of compounds 1- 9 in Z. jujuba fruits, an analytical method based on liquid chromatography coupled to mass spectrometry with ESI source and triple quadrupole analyzer (LC-ESI(QqQ)MS), using the very sensitive and selective mass tandem experiment called Multiple Reaction Monitoring (MRM), was developed and validated.Furthermore, the antiproliferative activity of compounds 1- 9 was determined on three different cultured cell lines, namely J774A.1, MCF7 and A459 cells[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Alphitolic acid

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途