苦艾素A3 TN1425

Product Introduction
Bioactivity


英文名: Bacoside A3

描述: Bacoside A3 是一种天然的三萜皂苷，是Bacopa monnieri 的主要活性成分之一，显示出神经保护活性。

体外活性: The cytoprotective effects of individual bacoside A components were evaluated towards oxidative stressed neuronal cells. Bacoside A was screened for neuronal cell viability (MTT assay) and change in intracellular reactive oxygen species (ROS), anti-apoptotic properties and mitochondrial membrane potential (MMP) using fluorescence microscopy. Different bacoside A components showed decrease in N2a cell viability below 100 (%) after bacoside A concentration of 0.4 mg/ml. Further, cytoprotective effect of optimized dose of bacoside A was analysed for alleviating oxidative stressed, apoptosis and MMP in H2 O2 stressed neuronal cells. Results showed increase in MMP, and decrease in apoptotic induction, without much change in nuclear integrity in stressed neuronal cells. Results showed Bacoside A3 and bacopaside II have comparatively higher cytoprotective ability whilst isomer of bacopasponin C, bacopasaponin C and mixture showed comparatively less response[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 60 mg/mL (64.58 mM)


关键字: Inhibitor | Bacoside A-3 | Bacoside A 3 | Bacoside A3 | inhibit

相关产品: Cytochalasin D | Isopulegol | (-)-Praeruptorin A | Suloctidil | Thevetin B | Ciclopirox | Diazoxide | Eniporide | Blebbistatin | D-α-Hydroxyglutaric acid disodium

相关库: Membrane Protein-targeted Compound Library | Neuronal Signaling Compound Library | Natural Product Library for HTS | Cuproptosis Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途