醉鱼草皂苷 Ⅳ TN1458
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 139523-30-1 | ¥4,650.00 | 询底价 |
5 mg | 139523-30-1 | ¥3,040.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Buddlejasaponin IV
描述: Buddlejasaponin IV has analgesic and anti-inflammatory effects, the inhibitions of the expressions of iNOS, COX-2, TNF-alpha, IL-1beta and IL-6 by blocking NF-kappaB activation.
体外活性: The study investigated whether Buddlejasaponin IV could prevent oral carcinogenesis by inhibiting the growth of immortalized human oral keratinocytes (IHOKs). Buddlejasaponin IV reduced cell viability and induced cell cycle arrest at G2/M phase and apoptotic morphological changes in IHOKs. Buddlejasaponin IV inhibited the levels of cyclin B1, Cdc2 and Cdc25C, but enhanced Chk2 phosphorylation. The increased levels of pRb and p21 protein and the activation of p53 were also noted in Buddlejasaponin IV-treated IHOKs. In addition, Buddlejasaponin IV induced cytochrome c release from mitochondria by reducing antiapoptotic Bcl-2 levels and increasing pro-apoptotic Bax levels. Buddlejasaponin IV treatment resulted in the activation of caspase-9 and caspase-3. PARP cleavage was also clearly observed in the Buddlejasaponin IV-treated IHOKs. Furthermore, the expression of the Fas death receptor and Fas ligand was induced and procaspase-8 level was suppressed by Buddlejasaponin IV treatment. Taken together, Buddlejasaponin IV treatment inhibited the growth of IHOK cells via the induction of p53-dependent cell cycle arrest at the G2/M phase and apoptosis via both mitochondrial-dependent and death receptor-mediated pathways[1]
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Buddlejasaponin IV
相关产品: Rucaparib monocamsylate | Veliparib dihydrochloride | PARP-1-IN-3 | E7449 | PI-1840 | PARP1-IN-8 | Veliparib | 5,7,4'-Trimethoxyflavone | ARTD10/PARP10-IN-1 | Zingiberen newsaponin
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途