碟豆素 TN1513
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 55804-74-5 | ¥1,200.00 | 询底价 |
100 mg | 55804-74-5 | ¥6,280.00 | 询底价 |
25 mg | 55804-74-5 | ¥2,990.00 | 询底价 |
50 mg | 55804-74-5 | ¥4,420.00 | 询底价 |
10 mg | 55804-74-5 | ¥1,770.00 | 询底价 |
1 mg | 55804-74-5 | ¥497.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Clitorin
描述: Clitorin 是一种山奈酚糖苷,分离自 Acalypha indica 的花和叶,表现出抗氧化活性。
体外活性: Antiplasmodial activity of extracts was confirmed and the active fractions in the extract were identified by HPLC-based activity profiling, a gradient HPLC fractionation of a single injection of the extract, followed by offline bioassay of the obtained microfractions. For preparative isolation of compounds, an alkaloidal fraction was obtained via adsorption on cationic ion exchange resin. Active compounds were purified by HPLC-MS and MPLC-ELSD. Structures were established by HR-ESI-MS and NMR spectroscopy. For compounds 5 and 7 absolute configuration was confirmed by comparison of experimental and calculated electronic circular dichroism (ECD) spectroscopy data, and by X-ray crystallography. Compounds were tested for bioactivity in vitro against four parasites (Trypanosoma brucei rhodesiense, Trypanosoma cruzi, Leishmania donovani, and Plasmodium falciparum), and in the Plasmodium berghei mouse model. Profiling indicated flavonoids and alkaloids in the active time windows. A total of nine compounds were isolated. Four were known flavonols--manghaslin, Clitorin, rutin, and nicotiflorin. Five compounds isolated from the alkaloidal fraction were piperidine alkaloids. Compounds 5 and 6 were inactive carpamic acid and methyl carpamate, while three alkaloids 7-9 showed high antiplasmodial activity and low cytotoxicity. When tested in the Plasmodium berghei mouse model, carpaine (7) did not increase the survival time of animals.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 60 mg/mL (81.01 mM)
关键字: Inhibitor | Clitorin | inhibit
相关产品: HA-100 | HA-1004 dihydrochloride | Palmitoylcarnitine chloride | A-674563 HCl (552325-73-2(free base)) | Staurosporine | R59949 | Gardenin A | Decursinol angelate | Midostaurin | PKC 20-28,myristoylated
相关库: Tobacco Monomer Library | Polyphenolic Natural Product Library | Chinese Pharmacopoeia Natural Product Library | Bioactive Compounds Library Max | Kinase Inhibitor Library | Epigenetics Compound Library | Traditional Chinese Medicine Monomer Library | Natural Product Library for HTS | TGF-beta/Smad Compound Library | Natural Product Library
碟豆素 TN1513信息由TargetMol中国为您提供,如您想了解更多关于碟豆素 TN1513报价、型号、参数等信息,欢迎来电或留言咨询。
注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途