去氢厄弗酚 TN1560

Product Introduction
Bioactivity


英文名: Dehydroeffusol

描述: Dehydroeffusol (Dehydro Effusol) 通过选择性诱导肿瘤抑制性内质网应激和中度细胞凋亡来抑制胃癌细胞生长和致瘤性，具有抗癌、抗焦虑和镇静作用。

体外活性: Dehydroeffusol selectively activated the intracellular tumor suppressive stress response by promoting the overexpression of the key ER stress marker DNA damage-inducible transcript 3 (DDIT3), through upregulation of activating transcription factor 4 (ATF4). Concurrently, Dehydroeffusol suppressed the expression of the cell survival and ER stress marker glucose regulated protein of molecular mass 78 (GRP78) via downregulation of the transcription factor ATF6. In addition, Dehydroeffusolmarkedly activated the stress response signaling pathway MEKK4-MKK3/6-p38-DDIT3, but significantly inhibited ERK signaling[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: inhibit | Inhibitor | Apoptosis | Dehydroeffusol

相关产品: Muscone | Excisanin A | MMP-7-IN-2 | MMP-12 Inhibitor | MMP-7-IN-3 | JNJ0966 | Doxycycline hydrochloride | BPHA | Glucosamine sulfate | MMP-3 Inhibitor

相关库: HIF-1 Signaling Pathway Compound Library | Membrane Protein-targeted Compound Library | GPCR Compound Library | Anti-Fibrosis Compound Library | Natural Product Library for HTS | Anti-Pancreatic Cancer Compound Library | Endocrinology-Hormone Compound Library | RO5 Drug-like Natural Product Library | Reprogramming Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途