钩藤碱 C TN2116

Product Introduction
Bioactivity


英文名: Pteropodine

描述: Pteropodine acts as a positive modulator of muscarinic M(1) and 5-HT(2) receptors. Pteropodine shows antigenotoxic, antioxidant and lymphocyte induction effects, it also shows strong apoptotic effect on acute leukaemic lymphoblasts.

体外活性: In this study, the effects of these alkaloids on the function of Ca(2+)-activated Cl(-) currents evoked by stimulation of G protein-coupled muscarinic M(1) acetylcholine and 5-HT(2) receptors were studied in Xenopus oocytes in which rat cortex total RNA was translated. Pteropodine and isoPteropodine (1-30 microM) failed to induce membrane current by themselves. However, these alkaloids markedly enhanced the current responses evoked by both acetylcholine and 5-hydroxyhyptamine (5-HT) in a concentration-dependent and reversible manner with the maximal effects at 30 microM. Pteropodine and isoPteropodine produced 2.7- and 3.3-fold increases in the acetylcholine response with EC(50) values of 9.52 and 9.92 microM, respectively, and 2.4- and 2.5-fold increases in the 5-HT response with EC(50) values of 13.5 and 14.5 microM, respectively. In contrast, in oocytes injected with total RNA from the rat cerebellum or spinal cord, neither alkaloid had an effect on the metabotropic current responses mediated by glutamate receptor(1 and 5) (mGlu(1/5)) receptors or ionotropic responses mediated by N-methyl-D-aspartate, kainic acid or glycine. Pteropodine and isoPteropodine (10 microM) significantly reduced the EC(50) values of acetylcholine and 5-HT that elicited current responses, but had no effect on the maximal current responses elicited by acetylcholine and 5-HT. On the other hand, mitraphylline, a stereoisomer of Pteropodine, failed to modulate acetylcholine- and 5-HT-induced responses.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Pteropodine

相关产品: AZD-5991 | Dehydrocorydaline chloride | Scutebarbatine A | (R)-(-)-Gossypol acetic acid | MIK665 | (S)-Purvalanol B | IMB-XH1 | Quercetin 3,4'-dimethyl ether | Cimidahurinine | Gossypol (acetic acid)

钩藤碱 C TN2116信息由TargetMol中国为您提供，如您想了解更多关于钩藤碱 C TN2116报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途