化合物Sappanchalcone TN2180

Product Introduction
Bioactivity


英文名: Sappanchalcone

描述: Sappanchalcone shows xanthine oxidase inhibitory activity, is a xanthine oxidase inhibitor.

体外活性: The influence of the ethyl acetate (EtOAc) extract of Lignum Sappan and its constituents on growth-related signaling were evaluated by a luciferase assay in cells stably-transfected with NF-κB, STAT1, or STAT3 responsive luciferase reporter plasmid. The inhibitory effect on the cell cycle was determined by flow cytometric analysis. The anti-tumor activities were assessed in vitro and in vivo. The EtOAc extract of Lignum Sappan had inhibitory activities on growth-related signaling and cell mitosis. Three major active compounds were Sappanchalcone, brazilin, and butein. Sappanchalcone blocked cell cycle progression in the G2/M phase, brazilin inhibited TNFα±/NF-κB signaling, while butein inhibited IL-6/STAT3 signaling, as well as TNFα±/NF-κB signaling. The three compounds all demonstrated cytotoxic activities against human tumor cells in vitro. In a S180 tumor cell-bearing mice model, the anti-tumor efficacy of the EtOAc extract was better than the individual compounds acting alone[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Sappanchalcone

相关产品: AF 12198 Acetate | EM 163 | Hirsutenone | Moringin | IL-17A antagonist 3 | Nodosin | Deacetylasperulosidic Acid | Anti-inflammatory agent 42 | Nudiposide | Umbelliprenin

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途