化合物 TN2977 TN2977
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mL | 121064-78-6 | ¥15,800.00 | 询底价 |
5 mg | 121064-78-6 | ¥13,500.00 | 询底价 |
Product Introduction
Bioactivity
英文名: 3-O-trans-p-Coumaroyltormentic acid
描述: 3-O-(E)-p-coumaroyl tormentic acid may be promising lead compound for developing an effective drug for treatment of leukemia, it induces apoptotic cell death in human leukemia (HL60) via mainly mitochondrial pathway by, at least in part, Topo I inhibition. 3-O-trans-p-coumaroyltormentic acid shows cytotoxicity against four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and HCT-15) in vitro, the IC50 values of 13.72, 14.29,14.61, 14.04 uM, respectively. 3beta-O-cis-p-Coumaroyltormentic acid, and 3beta-O-trans-p-coumaroyltormentic acid are weakly selective for vancomycin-resistant Enterococcus (VRE) compared with eukaryotic cells, with an MIC of 59.4microg/mL and a 50% inhibitory concentration (IC50) of 72.0microg/mL for monkey kidney epithelial (MA104) cells. A mixture of 3-O-cis-p-coumaroyltormentic acid and 3-O-trans-p-coumaroyltormentic acid shows an inhibitory effect comparable to (-)-epigallocatechin gallate (EGCG) of green tea on the activation of Epstein-Barr virus early antigen (EBV-EA) induced by 12-O-tetradeca--noylphorbol-13-acetate (TPA).
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: 3-O-trans-p-Coumaroyltormentic acid | 3OtranspCoumaroyltormentic acid | 3 O trans p Coumaroyltormentic acid
相关产品: Ac-IETD-CHO TFA | Lupiwighteone | Effusanin E | Asperosaponin VI | BOC-D-FMK | SACLAC | Phenoxodiol | Gardenin B | Ivachtin | Nivalenol
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途