N-(2-羟乙基)腺苷 TNU0429
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
50 mg | 4338-48-1 | ¥331.00 | 询底价 |
100 mg | 4338-48-1 | ¥495.00 | 询底价 |
1 mL | 4338-48-1 | ¥195.00 | 询底价 |
Product Introduction
Bioactivity
英文名: N6-(2-Hydroxyethyl)adenosine
描述: N6-(2-Hydroxyethyl)adenosine 是一种 Ca2+拮抗剂和抗炎剂,与脑和冠状动脉循环的控制有关,被认为具有镇静活性。
体外活性: N6-(2-Hydroxyethyl)adenosine can suppress TGF-β1 or LPS-induced TGF-β1/Smad and NF-κB signaling pathways in vitro. The levels of ECM production, indicated by expression of collagen I, α-SMA and Fibronectin, are significantly reduced by treatment with N6-(2-Hydroxyethyl)adenosine dose-dependently (5, 10, and 20 μg/ml). Similarly, TGF-β and LPS stimulate increased levels of TNF-α, IL-1β and IL-10. N6-(2-Hydroxyethyl)adenosine treatment reduces the elevated levels of TNF-α and IL-1β and increases IL-10 secretion dose-dependently [1].
体内活性: Injury of Kidney Tissue in UUO Mice Ameliorated by Intraperitoneal Administration of N6-(2-Hydroxyethyl) adenosine (2.5, 5, and 7.5 mg/kg; intraperitoneal injection). N6-(2-Hydroxyethyl) adenosine treatment prevents the accumulation of fibrosis-related proteins (TGF-β1, α-SMA, collagen I, and Fibronectin) and inflammatory cytokines (TNF-α, IL-6, IL-1β, and IL-10) associated with renal interstitial fibrosis. N6-(2-Hydroxyethyl) adenosine could block the accumulation of M1 macrophages, and induced the accumulation of M2 macrophages in ligated kidneys [1].
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 4.8 mg/mL (15.42 mM)
相关产品: Norverapamil | Azelnidipine | Etripamil | Manidipine dihydrochloride | Ginsenoside Rd | Levetiracetam | Kurtoxin | Norverapamil hydrochloride | Ebselen | Gypenoside L
相关库: Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途