化合物 TP2286 TP2286

Product Introduction
Bioactivity


英文名: Quinupristin (mesylate) (120138-50-3 free base)

描述: Quinupristin is a streptogramin antibiotic. Streptogramins, a class of antibiotics, is effective in the treatment of vancomycin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus, which are two of the most rapidly growing strains of multidrug-resistant bacteria. Streptogramins fall into two groups: streptogramin A and streptogramin B.

体外活性: In vitro: Quinupristin can bind to sequential sites located on the 50s subunit of the bacterial ribosome. Dalfopristin binding causes a conformational change in the ribosome that subsequently increases the binding of quinupristin. The combined actions of the two agents create a stable drug-ribosome complex causing inhibition of protein synthesis by prevention of peptide-chain formation, blockade of extrusion of newly formed peptide chains, and bacterial cell death [1].

体内活性: In vivo: The combination of quinupristin-dalfopristin (Q-D) and gentamicin was tested against two strains of gentamicin- and dalfopristin-susceptible methicillin-resistant Staphylococcus aureus (MRSA). A rabbit endocarditis model simulated the pharmacokinetics achieved in humans receiving intravenous injections of Q-D and gentamicin. For the MLSB-susceptible strain, a 4-day regimen reduced mean bacterial titers (MBT) in vegetations from 8.5 ± 0.8 logs CFU/g (control group) to 3.0 ± 0.9 (Q-D) and 2.6 ± 0.5 logs CFU/g (Q-D plus gentamicin). For the strain constitutively resistant to MLSB, a 4-day regimen reduced MBT in vegetations from 8.7 ± 0.9 logs CFU/g (control group) 5.2 ± 2.2 (Q-D) and 5.1 ± 2.4 log CFU/g (Q-D plus gentamicin). The differences between control and treatment groups were significant for both strains, although there was no significant difference between treatment groups [2].

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Soluble
Ethanol : Soluble


关键字: Quinupristin (mesylate) (120138503 free base) | Quinupristin (mesylate) (120138 50 3 free base) | 120138-50-3 | 120138-50-3 free base | Quinupristin

化合物 TP2286 TP2286信息由TargetMol中国为您提供，如您想了解更多关于化合物 TP2286 TP2286报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途