蓝萼乙素 B TQ0309

Product Introduction
Bioactivity


英文名: Glaucocalyxin B

描述: Glaucocalyxin B 是从碎米桠中分离出来的二萜类天然产物，可降低 HL-60 细胞的生长，IC50为 5.86 μM，具有抗癌和抗肿瘤活性。

细胞实验: The microglia cell viability is assessed by MTT assay. Cells are seeded in 96-well plates at the density of 5 × 10^4 cells/well. The cell culture supernatant is discarded after treatment with various agents, and then 30 μL of MTT (0.5 mg/mL) solution is added into each well. After incubation for 4 h at 37 °C, 100 μL of DMSO is added into each well to dissolve the formazan dye, and then the absorbance of solubilized formazan is measured by microplate reader [3].

体外活性: Glaucocalyxin A (GlnA)和(GlnB)能够剂量依赖性地降低HL-60细胞的生长（24小时的IC50分别为6.15和5.86μM）。Gln A和B均可诱导HL-60细胞的细胞凋亡、G2/M期阻滞、DNA损伤以及活性氧（ROS）的积累[1]。GlnB通过诱发细胞凋亡和自噬，抑制了人类宫颈癌细胞的体外增殖，这一作用可能是通过磷脂酰肌醇4,5二磷酸3激酶/Akt信号通路介导的。GlnB对HeLa和SiHa宫颈癌细胞系的增殖具有剂量依赖性抑制作用，增加了凋亡细胞群体并增强了多(ADP核糖)聚合酶1的切割[2]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : Soluble


关键字: Inhibitor | inhibit | Glaucocalyxin B | Autophagy

相关产品: AM580 | Bafetinib | Leonurine | UVI 3003 | Bexarotene | Sulfacetamide sodium | Dioscin | Deferoxamine Mesylate | JZL195 | SD 0006

相关库: RO5 Drug-like Natural Product Library | Rare Natural Product Library

蓝萼乙素 B TQ0309信息由TargetMol中国为您提供，如您想了解更多关于蓝萼乙素 B TQ0309报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途