4-氨基安替比林 T0050

Product Introduction
Bioactivity


英文名: Ampyrone

描述: Ampyrone (4-Aminoantipyrine) 是一种检测试剂，在过氧化物酶与苯酚存在时，用于葡萄糖测定。

细胞实验: Erythrocytes in PBS are incubated for 2 h at ambient temperature (without mixing) with AAP in concentrations from 1 × 10−6 mol/L to 1 × 10−3 mol/L. Sample of erythrocytes without AAP is used as control. After the exposure of AAP, erythrocytes are washed with borate buffer (pH 9.0) 2 times by centrifuging and determined for GSH. (Only for Reference)

体外活性: The level of glutathione(GSH) in single erythrocytes is impacted slightly at low AAP(4-aminoantipyrine) concentrations probably due to the protection of glutathione reductase. When AAP concentration further increases, AAP has a significant influence on GSH[2].

体内活性: 4-aminoantipyrine (4-AA) is not genotoxic and mutagenic in vivo, it can interfere with DNA damaging agents biological activities and may reduce the effectiveness of DNA damage-based chemotherapy[3].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 40 mg/mL (196.81 mM)
H2O : 37 mg/mL(182.1 mM)


关键字: Inhibitor | NSC60242 | Cyclooxygenase | Drug Metabolite | Ampyrone | COX | inhibit | NSC-60242

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途