恩替卡韦 T0085L

Product Introduction
Bioactivity


英文名: Entecavir

描述: Entecavir (SQ34676) 是一种选择性 HBV 抑制剂，在 HepG2细胞中的 EC50值为3.75 nM。

细胞实验: BMS 200475 is prepared in phosphate-buffered saline (PBS) and diluted with appropriate medium containing 2% fetal bovine serum. HepG2 2.2.15 cells are plated at a density of 5×105 cells per well on 12-well Biocoat collagen-coated plates and are maintained in a confluent state for 2 to 3 days before being overlaid with 1 mL of medium spiked with BMS 200475. Quantification of HBV was performed on day 10[1].

体外活性: BMS-200475抑制HBV蛋白引物（EC50 值为 3.75 nM），抑制反转录酶的启动。与其他抗RNA和DNA病毒化合物相比，BMS-200475的抗病毒活性显著下降[1]。相对于其他脱氧鸟苷类似物（penciclovir、ganciclovir、lobucavir、aciclovir 或 lamivudine），BMS-200475更容易被磷酸化为其活性代谢物。BMS-200475 的细胞内半衰期为15小时[2]。

体内活性: BMS-200475（p.o ,剂量自0.02至0.5 mg/kg体重，连续1至3个月治疗）能有效降低慢性感染土拨鼠中的土拨鼠乙型肝炎病毒（WHV）血症水平[3]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 55 mg/mL (198.36 mM)


关键字: HBV | BMS-200475 | Hepatitis B virus | SQ 34676 | SQ-34676 | BMS 200475 | inhibit | Inhibitor | Entecavir

相关产品: Helioxanthin derivative 5-4-2 | Lagociclovir | Periglaucine A | Besifovir | Kurarinol | Mulberrofuran G | Tenofovir | HBV-IN-38 | Linvencorvir | Chamaechromone

相关库: Nucleotide Compound Library | Drug Repurposing Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Clinical Compound Library | Pediatric Drug Library | Anti-Cancer Approved Drug Library | EMA Approved Drug Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途