盐酸阿比多尔 T0104

Product Introduction
Bioactivity


英文名: Umifenovir hydrochloride

描述: Umifenovir hydrochloride (Arbidol HCl) 是一种口服有效的广谱抗病毒药物，对多种包膜和非包膜病毒均有活性。它被用作抗流感病毒剂，可通过阻断病毒与宿主细胞膜的融合来抑制包膜病毒的细胞侵袭。它是一种 SARS-CoV-2 抑制剂，具有抗炎活性。

体外活性: Arbidol inhibits the cell entry of HCV pseudoparticles of genotypes 1a, 1b, and 2a in a dose-dependent fashion. Arbidol also displays a dose-dependent inhibition of HCV membrane fusion, as assayed by using HCV pseudoparticles (HCVpp) and fluorescent liposomes. [1] Arbidol is found to present potent inhibitory activity against enveloped and non-enveloped RNA viruses, including FLU-A, RSV, HRV 14 and CVB3 when added before, during, or after viral infection, with IC50 ranging from 2.7 to 13.8 mg/mL. Arbidol shows selective antiviral activity against AdV-7, a DNA virus, only when added after infection (therapeutic index (TI) = 5.5). [2] Arbidol induces changes to viral mRNA synthesis of the PB2, PA, NP, NA, and NS genes in MDCK cultures infected with influenza A/PR/8/34. [3] Arbidol interacts and modifies the physicochemical properties of the phospholipids in the membrane, having a significant effect on negatively charged phospholipids but a minor one on zwitterionic phospholipids. Arbidol is located at the interface of the membrane, participates in hydrogen bonding either with water or the phospholipid or both, and decreases the hydrogen bonding network of the phospholipids giving place to a phospholipid phase similar to the dehydrated solid one. [4] Arbidol is found to have potent inhibitory activity against HTNV when added in vitro before or after viral infection, with IC50 of 0.9 mg/mL and 1.2 mg/mL, respectively. [5]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 21 mg/mL (40.9 mM)
DMSO : 45 mg/mL (87.57 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)


关键字: SARS coronavirus | inflammatory | fusion | Umifenovir hydrochloride | SARS-CoV | Arbidol Hydrochloride | Inhibitor | enveloped | oral | virus | inhibit | Influenza Virus | Umifenovir Hydrochloride | Umifenovir

相关产品: Simaravibart | GNF-5 | Andrographolide | PLpro inhibitor | Indinavir sulfate | SARS-CoV-2-IN-65 | SARS-CoV-2-IN-66 | SARS-CoV-2-IN-63 | SARS-CoV-2 Mpro-IN-8 | 4'-O-Methylbavachalcone

相关库: Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library | Clinical Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Target-Focused Phenotypic Screening Library | Anti-Viral Compound Library | Anti-Infection Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途