盐酸表柔比星 T0125

Product Introduction
Bioactivity


英文名: Epirubicin hydrochloride

描述: Epirubicin hydrochloride (Pharmorubicin) 是一种阿霉素的半合成 L-阿拉伯糖衍生物，是一种 Forkhead box 蛋白 p3 抑制剂，可抑制调节性 T 细胞活性。它抑制 DNA 和 RNA 合成，还能够抑制拓扑异构酶，起抗肿瘤作用。

细胞实验: Hep G2 cells (500 cells/well, monolayer) are plated in a 96-well plate. The next day the cells are treated with Epirubicin in the medium. At the end of the incubation periods, 15% volume of MTT dye solution is added. After 1 hr of incubation at 37℃, an equal volume of solubilization/stop solution (dimethylsul-foxide) is added to each well for an additional 1 hr incubation. The absorbance of the reaction solution at 570 nm is recorded.(Only for Reference)

体外活性: 在3.5 mg/kg剂量下,Epirubicin可以抑制74.4%人类乳腺肿瘤异种移植的R-27的肿瘤块.Epirubicin对很多类型的肿瘤具有临床活性,包括乳腺癌,恶性淋巴瘤,软组织肉瘤,肺癌,胸膜间皮瘤,胃肠癌,头颈癌,卵巢癌,前列腺癌,移行膀胱癌等.

体内活性: Epirubicin对大多数癌细胞表现出抗肿瘤活性。1.6 μg/mL Epirubicin引起Hep G2细胞凋亡,使过氧化氢酶活性、Se-依赖性谷胱甘肽过氧化物酶活性、Cu,Zn-超氧化物歧化酶活性和Mn-超氧化物歧化酶活性分别提高50%,110%,172%和135%。Epirbicin增加NADPH-CYP 450还原酶在细胞中的表达,并减少GST-π的表达。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: 5% DMSO+95% Saline : 2.9 mg/mL (5 mM)
DMSO : 42.86 mg/mL (73.89 mM)
Ethanol : 5.8 mg/mL (10 mM)


关键字: 4'-Epidoxorubicin | Apoptosis | DNA/RNA Synthesis | Epirubicin hydrochloride | L-arabino | Epirubicin Hydrochloride | Inhibitor | Foxp3 | Epirubicin | 4'-Epidoxorubicin Hydrochloride | derivative | cell | inhibit | Topoisomerase

相关产品: ISRIB (trans-isomer) | SC-236 | Swainsonine | Kaerophyllin | PG-11047 2HCl | Concanavalin A | PROCYANIDIN C1 | Physalin B | Solamargine | SZL P1-41

相关库: Drug Repurposing Compound Library | Anti-Liver Cancer Compound Library | FDA-Approved & Pharmacopeia Drug Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Active Compound Library | Anti-Cancer Approved Drug Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途