盐酸奈必洛尔 T0154

Product Introduction
Bioactivity


英文名: Nebivolol hydrochloride

描述: Nebivolol hydrochloride (R 065824 hydrochloride) 是一种β1-肾上腺素受体选择性抑制剂，IC50为0.8 nM。

细胞实验: Cells are exposed to different concentrations of Nebivolol (10-7~10-5 M) for 1, 2, 4, 7 and 14 days. Cell proliferation is analyzed by bromodeoxyuridine (BrdU) incorporation, and cell apoptosis is detected by PI or annexin V staining.(Only for Reference)

体外活性: Nebivolol处理患心肌梗塞大鼠,少量降低平均血压.开始静脉注射Nebivolol 10分钟,然后再口服处理患有心肌梗塞的大鼠,可以降低心肌凋亡.

体内活性: Nebivolol可以降低冠状动脉平滑肌细胞(haCSMCs)及内皮细胞(haECs)增殖,这种作用存在浓度和时间依赖性。Nebivolol在制备兔肺膜时,作用于beta 1-肾上腺素受体位点具有高亲和性和高度选择性。Nebivolol处理haCSMCs7天,明显抑制细胞增殖（IC50：6.1 μM）。Nebivolol处理haCSMCs 48小时,细胞凋亡率23%,且降低S期细胞数量。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 4.4 mg/mL (10 mM)
DMSO : 44.2 mg/mL (100 mM)


关键字: R-065824 Hydrochloride | adrenergic blocking | Adrenergic Receptor | ischemic heart disease | R65824 | R 065824 | congestive heart failure | coronary artery disease | R065824 | Nebivolol | oral | inhibit | hypertension | R 065824 Hydrochloride | Nebivolol hydrochloride | Inhibitor | R065824 Hydrochloride | Beta Receptor | vasodilator | R 65824 | Apoptosis | R-065824 | Nebivolol Hydrochloride

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途