氯沙坦钾 T0215

Product Introduction
Bioactivity


英文名: Losartan potassium

描述: Losartan potassium (DuP-753 potassium) 是一种血管紧张素 II 受体 1 型(AT1)拮抗剂，能够与血管紧张素 II 与 AT1 的结合竞争,其 IC50=20 nM。

细胞实验: An MTT assay is used to measure cell proliferation and viability. For the assay, 5000 cells in 200?μL media per well are seeded in a 96 well plate. After overnight incubation to allow for cell attachment, the medium is removed by suction. MTT at 1?mg/mL concentration in serum-free medium is added and then incubated for 4?h at 37°C. After removal of MTT solution, 100?μL of DMSO is added to dissolve formazan crystals. Absorbance at 570?nm and at 600?nm as a reference is then measured using a microplate reader. The difference in absorbance is thus relative to the extent of cell survival.

体外活性: Losartan 与血管紧张素II竞争性地结合AT1受体。其抑制血管紧张素II结合50%所需浓度（IC50）为20 nM[1]。Losartan （40μM）影响ISC，但可阻止ANGII对ISC的作用[2]。Losartan 显著降低血管紧张素II介导的子宫内膜癌细胞增殖。Losartan 与抗miR-155联合使用，相比单药治疗具有更显著的抑制增殖效果[3]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 46.1 mg/mL (100 mM)
DMSO : 55 mg/mL (119.3 mM)


关键字: Angiotensin Receptor | MK954 | inhibit | Losartan | Losartan potassium | DuP-753 | DuP753 | MK-954 | Inhibitor

相关产品: Vicenin 3 | Camellianin A | Rentiapril | Leucosceptoside A | N-Acetyl-Ser-Asp-Lys-Pro | Peimisine | H-Val-Pro-Pro-OH | Sinapinic Acid | Angiotensin (1-7) | Angiotensin II human

相关库: Anti-Aging Compound Library | Drug Repurposing Compound Library | Approved Drug Library | FDA-Approved & Pharmacopeia Drug Library | Membrane Protein-targeted Compound Library | Anti-Metabolism Disease Compound Library | Inhibitor Library | Pediatric Drug Library | Anti-Diabetic Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途