美罗培南 T0224
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
100 mg | 96036-03-2 | ¥587.00 | 询底价 |
50 mg | 96036-03-2 | ¥418.00 | 询底价 |
25 mg | 96036-03-2 | ¥292.00 | 询底价 |
500 mg | 96036-03-2 | ¥1,449.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Meropenem
描述: Meropenem (SM 7338) 是一种具有广谱抗菌活性的碳青霉烯抗生素,对敏感和耐药的淋病奈瑟氏球菌,流感嗜血杆菌和杜克氏杆菌的 MIC 值分别为 0.02-0.06 mg/mL,0.03-0.12 mg/mL 和 0.015-0.12 mg/mL。
激酶实验: Complementation of SCR7 Inhibition with Puri?ed Ligase IV: Complementation experiment is carried out by adding increasing concentrations of puri?ed Ligase IV/XRCC4 complex (30, 60, and 120 fmol) along with the oligomeric DNA substrates (5' compatible and 5'-5' noncompatible ends) to the SCR7-treatedextracts. Reactions are incubated for 2 h at 25℃. The reaction products are then resolved on 8% denaturing PAGE. The gel is dried and exposed and the signal is detected with a PhosphorImager and analyzed with Multi Gauge (V3.0) software.
体外活性: Meropenem明显提高兔体内丙戊酸-葡萄糖醛酸在尿中的排泄.
体内活性: Meropenem具有类似于亚胺培南的抗菌谱,但对葡萄状球菌和肠球菌的活性略低,它对绿脓杆菌、所有的肠杆菌科和流感嗜血杆菌具有更强的活性。Meropenem对革兰氏阴性生物体的抗微生物活性是亚胺培南的两到四倍,其抗菌谱比测试的所有其他药物更宽。Meropenem与其他几个β-内酰胺类抗株产I型头孢菌素有拮抗效应。Meropenem最强烈地结合大肠杆菌和绿脓杆菌的青霉素结合蛋白2和金黄色葡萄球菌的青霉素结合蛋白1。
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 4.23 mg/mL (11.03 mM)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)
H2O : 8 mg/mL (20.86 mM)
关键字: anaerobic | parenteral | neutropenia | Gram-positive | Inhibitor | SM7338 | DHP-1 | carbapenem | β-lactamases | Bacterial | Gram-negative | SM-7338 | Meropenem | Antibiotic | inhibit
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相关库: Drug Repurposing Compound Library | Approved Drug Library | Antibiotics Library | ReFRAME Related Library | FDA-Approved & Pharmacopeia Drug Library | Clinical Compound Library | Bioactive Compounds Library Max | Pediatric Drug Library | EMA Approved Drug Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途