盐酸倍他洛尔 T0226

Product Introduction
Bioactivity


英文名: Betaxolol hydrochloride

描述: Betaxolol hydrochloride (SL 75212 HCl) 是一种 β1 肾上腺素受体阻断剂，可用于研究高血压和青光眼。

细胞实验: Dissociated cortical cells from 16–18-day-old fetal rats are grown, in 35 mm dishes, in DMEM supplemented with L-glutamine (4 mM), glucose (6 g/L), penicillin (100 U/mL), streptomycin (100 μg/mL) and 10% hormonal supplemented medium consisting of transferrin (1 mg/mL), insulin (250 μg/mL) putrescine (600 μM), sodium selenite (0.3 μM), progesterone (0.2 μM) and estradiol (0.1 pM) for 7 days in an atmosphere of 5% CO2/95% O2 at 37 °C. The cultures are then transferred to a culture medium which lacks the hormonal supplemented medium. L-glutamate is added to the medium and incubated for a further 4 hours under normoxic conditions. Betaxolol are added to the cultures at the same time as L-glutamate. In other experiments the cultures are subjected to anoxic conditions, 95% N2/5% CO2, for 5 hours at 37 °C. Betaxolol is added prior to anoxia. Reoxygenation is then achieved by replacing the cells in normoxic conditions (95% O2/5% CO2) for 3 hours. Cellular injury is assessed by measuring lactate dehydrogenase (LDH) release into the cell culture supernatant after hypoxia/reoxygenation or glutamate exposure. LDH activity is assayed spectrophotometrically by following NADH metabolism for 2 minutes at 340 nm.(Only for Reference)

体外活性: Betaxolol 的内含物可以部分阻止NMDA 和缺氧/ 葡萄糖引起的改变.在大鼠局部贫血前和再灌注损伤的时候腹腔注射Betaxolol可以有效减少钙网膜蛋白和ChAT免疫反应性的改变,并且可以阻止b波下降.

体内活性: 10 μM Betaxolol基本可以完全阻断谷氨酸酯诱导的LDH的释放。 100 μM Betaxolol能有效防止皮质组织中由缺氧引起的LDH的释放。Betaxolol能保护视网膜神经元。Betaxolol在β-肾上腺素受体激动剂无效时,会减弱NMDA诱导的45Ca2+流入。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (145.4 mM)
H2O : 29.08mM


关键字: Betaxolol hydrochloride | Beta Receptor | SL 75212 | Inhibitor | inhibit | Betaxolol Hydrochloride | Betaxolol | SL-75212 | Adrenergic Receptor

相关产品: Promethazine | Dexmedetomidine hydrochloride | Indacaterol maleate | Dobutamine hydrochloride | Ifenprodil | Rauwolscine hydrochloride | RS 15385-198 | Escitalopram | Ziprasidone hydrochloride | Labetalol hydrochloride

相关库: Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Anti-Cancer Drug Library | Coagulation and Anticoagulation Compound Library | Membrane Protein-targeted Compound Library | GPCR Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library | Endocrinology-Hormone Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途