莫西沙星盐酸盐 T0331

Product Introduction
Bioactivity


英文名: Moxifloxacin hydrochloride

描述: Moxifloxacin hydrochloride (BAY12-8039 HCl) 是一种口服有效的 8-甲氧基喹诺酮类抗菌药物，可研究感染性肺炎，急性细菌性鼻窦炎和慢性支气管炎的急性细菌性加重。

体外活性: 在模拟人体疾病的小鼠体内,与用异烟肼/利福平/吡嗪酰胺相比,Moxioxacin结合RIF/吡嗪酰胺减少2个月的治疗时间.类似的,利福平/Moxioxacin/吡嗪酰胺一周两次处理小鼠,在4个月之后达到稳定治愈,而利福平/异烟肼/吡嗪酰胺每天处理一次,6个月后治愈.

体内活性: Moxioxacin具有广谱的抗菌活性,对金黄色酿脓葡萄球菌,肺炎链球菌,化脓性链球菌,流感嗜血杆菌,H. parainuenzae,肺炎克雷伯菌,卡他莫拉菌,肺炎衣原体以及肺炎支原体表现出体外和临床活性。Moxioxacin通过诱捕DNA-药物-酶复合物发挥作用,其抑制了ATP依赖性的拓扑异构酶II（DNA促旋酶）和拓扑异构酶IV。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 15 mg/mL(34.3 mM)
DMSO : 88 mg/mL (200.96 mM)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)


关键字: Moxifloxacin | exacerbations | bronchitis | BAY 128039 | community-acquired | chronic | acute | Moxifloxacin Hydrochloride | Antibiotic | Moxifloxacin hydrochloride | sinusitis | BAY128039 | antimicrobial | BAY 12-8039 | Bacterial | inhibit | 8-methoxyquinolone | Inhibitor | pneumonia

相关产品: Camptothecin | Topoisomerase II inhibitor 15 | Lupalbigenin | Proscillaridin A | Exatecan Mesylate | 9-Hydroxycamptothecin | Isosteviol | Oxaquin TEA | Fleroxacin | Genz-644282

相关库: Anti-Aging Compound Library | Drug Repurposing Compound Library | Antibiotics Library | Drug-induced Liver Injury (DILI) Compound Library | FDA-Approved & Pharmacopeia Drug Library | Cardiotoxicity Compound Library | Bioactive Compounds Library Max | Orally Active Compound Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途