异戊酰胺 T0361

Product Introduction
Bioactivity


英文名: Isovaleramide

描述: Isovaleramide (3-Methylbutanamide) 是抗惊厥剂，能够调节中枢神经系统的活性。

体外活性: 研究Isovaleramide对小鼠,大鼠和兔的生殖毒性,其潜能远低于VPA.小鼠口服100 mg/Kg Isovaleramide,对最大电休克发作的保护指数达90％.

体内活性: 0.15% Isovaleramide在Rhodococcus sp. YH 3-3中诱导形成腈水合酶。300 μM Isovaleramide在体外实验中,抑制42% 3H-FNZ结合到位点。Isovaleramide浓度高达1000 μM时,不影响体外各种神经递质结合和吸收检测,说明其作用机制不涉及直接的受体介导作用。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 16 mg/mL (158.2 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 16 mg/mL (158.2 mM)


关键字: inhibit | Isovaleramide | Inhibitor

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相关库: Anti-Tumor Natural Product Library | Drug Repurposing Compound Library | ReFRAME Related Library | Tobacco Monomer Library | Clinical Compound Library | Anti-Metabolism Disease Compound Library | Natural Product Library for HTS | RO5 Drug-like Natural Product Library | NO PAINS Compound Library | Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途