氯磺丙脲 T0490

Product Introduction
Bioactivity


英文名: Chlorpropamide

描述: Chlorpropamide (Diabinese) 是口服降糖剂，可用于研究非胰岛素依赖型糖尿病。

激酶实验: Androgen Receptor Assay: Aliquots of 100 μl cytosol are incubated at 0-4°C for 18 h with 100 μl of the indicated saturating concentration of [3H]T in the presence or absence of increasing concentrations of nonlabeled T, DHT, flutamide (FLU) or flutamide-OH (FLU-OH). At the end of the incubation, free and bound T are separated by the addition of 200 μl dextran-coated charcoal (1 % charcoal, 0.1% dextran T-70, 0.1% gelatin, 1.5 mM EDTA and 50 mM Tris (pH 7.4)) for 15 min before centrifugation at 2300 × g for another 15 min at 0-4°C. Aliquots (350 μl) of the supernatant are transferred to scintillation vials with 10 ml of an aqueous counting solution before counting in a Beckman LS 330 counter.

体内活性: 0.2 mM的Chlorpropamide提高了家鼠体内分离出的肝细胞中fructose-2,6-bisphosphate (F-2,6-P2)的浓度。Chlorpropamide通过环AMP-非依赖性机制发挥作用。Chlorpropamide会增强胰岛素对胰高血糖素受激的糖异生的抑制作用。在胰岛素缺乏（30％）或者存在（31％）的情况下,Chlorpropamide都能显著增加葡萄糖代谢和总脂质。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 51 mg/mL (184.3 mM)
DMSO : 55 mg/mL (198.74 mM)


关键字: Sodium potassium pump | inhibit | Na+/K+ ATPase | Chlorpropamide | Inhibitor

相关产品: AGN-201904 | Isopulegol | Acevaltrate | Paederosidic acid methyl ester | Oleic acid | Prilocaine hydrochloride | Mitiglinide Calcium | Licoflavone B | Echinatine | Ciliobrevin D

相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | Approved Drug Library | ReFRAME Related Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Anti-Cancer Approved Drug Library | Orally Active Compound Library | Bioactive Compound Library

氯磺丙脲 T0490信息由TargetMol中国为您提供，如您想了解更多关于氯磺丙脲 T0490报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途