化合物XCT790 T0593

Product Introduction
Bioactivity


英文名: XCT790

描述: XCT790 是 ERRα的一种选择性反向激动剂，IC50值为 0.37 μM。它在化疗过程中诱导癌细胞死亡。

激酶实验: The inhibition of SHP2 from the tested compounds (SHP099) concentrations varying from 0.003-100 μM is monitored using an assay in which 0.5 nM of SHP2 is incubated with of 0.5 μM of peptide IRS1_pY1172(dPEG8)pY1222. After 30-60 minutes incubation at the surrogate substrate, DiFMUP is added to the reaction and incubated at 25 °C for 30 minutes. The reaction is then quenched by the addition of 5 μL of a 160 μM solution of bpV(Phen). The fluorescence signal is monitored using a microplate reader using excitation and emission wavelengths of 340 nm and 450 nm, respectively[1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 21 mg/mL (35.21 mM)


关键字: XCT 790 | Inhibitor | Estrogen Receptor/ERR | Autophagy | XCT-790 | inhibit | XCT790

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相关库: Anti-Aging Compound Library | Bioactive Compounds Library Max | Human Metabolite Library | Nuclear Receptor Compound Library | Anti-Cancer Active Compound Library | Apoptosis Compound Library | Autophagy Compound Library | Target-Focused Phenotypic Screening Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途