柚皮苷 T0595

Product Introduction
Bioactivity


英文名: Naringin

描述: Naringin (Naringoside) 是一种黄烷酮糖苷，有抗氧化活性、降血脂、抗癌和抑制细胞色素P450酶的药理作用。

细胞实验: HBZY-1 cells are plated into 96-well plates and pretreated with various concentrations(1, 5, 10, 25, 50, 100 μM) of naringin for 2 h. Then cells are treated with 30 mM glucose for 24 h. The control group is added sterile normal saline in the same volume. After treatment, all the wells are incubated with 20 μL of 5 mg/ml MTT for 4 h at 37°C. Subsequently, 100 μL of DMSO are used to dissolve the formed formazan crystals after removal of the supernatant. The result is recorded at 490 nm on a microplate reader[1].

体内活性: Naringin对小鼠的半数致死剂量（Lethal Dose 50）为1650 mg/kg。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 1 mg/mL (1.7 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 50 mg/mL (86.13 mM)


关键字: Mitochondrial Autophagy | inhibit | Endogenous Metabolite | Inhibitor | Autophagy | Naringin | Mitophagy | Cytochrome P450 | CYPs

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相关库: Drug Repurposing Compound Library | Anti-Inflammatory Traditional Chinese Medicine Compound Library | Tobacco Monomer Library | Anti-Cancer Drug Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Traditional Chinese Medicine Monomer Library | Anti-Cancer Active Compound Library | Metabolism Compound Library | Anti-infective Natural Product Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途