呋喃唑酮 T0751

Product Introduction
Bioactivity


英文名: Furazolidone

描述: Furazolidone (Furoxone) 是一种具有抗菌和抗原虫活性的硝基呋喃衍生物，抑制AML1-ETO 转化细胞，IC50为12.7 μM。

细胞实验: Leukemic cells are seeded in 96-well culture plates at a density of 1 or 2×104 viable cells/100 µl/well in triplicates and are treated for 24, 48, and 72 hours with an incremental concentration of FZD ranging from 1 µM to 50 µM. Colorimetric CellTiter 96® Aqueous One Solution Cell Proliferation assay is used to determine the cytotoxicity. The optical density at 492 nm is measured using a Multiskan Ascent® microplate photometer. IC50 values are determined by MTS assay when cells are treated with FZD for 72 hours and calculated with GraphPad Prism 5. Each experiment was in triplicate. (Only for Reference)

体外活性: Furazolidone在亚微摩尔浓度下展现出强大的抗增殖特性，并在AML细胞系中诱导凋亡。对特定AML细胞的Furazolidone处理通过形态学和流式细胞术检测CD11b表达来诱导髓系细胞分化诱导 AML细胞中肿瘤抑制蛋白p53稳定性增加[1]。

体内活性: FZ通过诱导CPR的活性，在鸡中加速自身的代谢，而在大鼠体内未观察到这种效果[2]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 7.5 mg/mL (33.31 mM)


关键字: Antibiotic | Inhibitor | Bacterial | inhibit | Furazolidone | Apoptosis

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相关库: Drug Repurposing Compound Library | Mitochondria-Targeted Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Neuronal Signaling Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library | Anti-Parasitic Compound Library | Orally Active Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途