磺胺多辛 T0836

Product Introduction
Bioactivity


英文名: Sulfadoxine

描述: Sulfadoxine (Sulphadoxine) 是磺胺类化合物，常与pyrimethamine 结合起到抗疟疾作用。它抑制HIV 在外周血单核细胞中的复制。

激酶实验: Competitive binding assays: Cells are harvested from 150-sq cm T-flasks, and cytosol is prepared at a protein concentration of approximately 2 mg/mL in phosphate buffer. Aliquots of this 180,000 ×g supernatant are then incubated with various concentrations of Tamoxifen and 2.5 nM [3H]estradiol for 16 hr at 0-4 ℃. The free steroids are absorbed by dextran-charcoal [l0 μL of 0.5% Dextran C-5% Norite A in TE buffer] for 1 hr at 0 ℃, and aliquots are counted after centrifugation at 800 ×g, 30 min. The relative binding ability of each competitor is taken as the ratio of the concentration of radioinert estradiol/competitor required to inhibit one-half of the specific [3H]estradiol binding, with the affinity of estradiol set at 100%.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 57 mg/mL (183.7 mM)
H2O : < 1 mg/mL (insoluble or slightly soluble)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)


关键字: HIV | Parasite | Sulfadoxine | Human immunodeficiency virus | inhibit | Antibiotic | Inhibitor

相关产品: Sulfameter | Pyrimethamine | Lometrexol | Pelitrexol | Gentamicin sulfate | Fanotaprim | WR99210 | Trioxsalen | 10-Formylfolic acid | (Rac)-Managlinat dialanetil

相关库: Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | Antibiotics Library | FDA-Approved & Pharmacopeia Drug Library | Anti-Cancer Drug Library | Anti-Cancer Clinical Compound Library | Anti-Parasitic Compound Library | Anti-Cancer Approved Drug Library | Metabolism Compound Library | Anti-Viral Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途