普罗帕酮 T0866

Product Introduction
Bioactivity


英文名: Propafenone

描述: Propafenone (Propafenonum) 是钠通道阻滞剂，它对 β 受体具有高亲和力 (IC50=32 nM)。它能够阻断瞬时外向钾电流 (Ito) (IC50: 4.9 nM) 和持续延迟整流器K+电流 (Isus) (IC50: 8.6 nM) ，具有抗心律失常的作用。它能够诱导线粒体功能障碍及诱导细胞凋亡，从而抑制食管癌增殖。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 25 mg/mL (73.22 mM)


关键字: Isus | Propafenone | KcsA | Drug repositioning | mitochondria dysfunction | SA-79 | apoptosis | Potassium Channel | esophageal | Ito | SA79 | Adrenergic Receptor | inhibit | ESCC | antiarrhythmic agent | mitochondrial dysfunction | Na+ channels | Inhibitor | SA 79 | Beta Receptor | sodium-channel blocker | Sodium Channel | Na channels

相关产品: RY785 | Cholesterol myristate | Alismol | BMS-919373 | κM-Conotoxin RIIIJ | Maralixibat Chloride | Disopyramide | ICA 110381 | Jingzhaotoxin-XII | Pinacidil monohydrate

相关库: FDA-Approved Drug Library | Drug Repurposing Compound Library | Mitochondria-Targeted Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Target-Focused Phenotypic Screening Library | NO PAINS Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途