壬二酸 T0926

Product Introduction
Bioactivity


英文名: Azelaic acid

描述: Azelaic acid (Anchoic acid) 是头发和皮肤调理剂的组分，可由油酸臭氧分解产生。Azelaic acid 通过抑制微生物细胞原蛋白合成对痤疮丙酸杆菌和表皮葡萄球菌具有抑菌活性。Azelaic acid 还具有抑制色素沉着的功能，这是由于其清除自由基作用。

细胞实验: B16F10 melanoma cells are seeded at a density of 2.5×105 cells/60 mm culture dish. The cells are treated with Azelaic acid combined with Tau for 24 hr. The cells pellets are dissolved in 1 N NaOH at 60°C for 1 hr. The relative melanin content is determined by measuring the absorbance at 475 nm in ELISA reader. (Only for Reference)

体外活性: AZ（Azelaic acid）与taurine（Tau）联合使用在黑色素细胞中表现出比单独使用AZ更强的抑制效果。AZ与Tau的组合不仅能显著抑制B16F10黑色瘤细胞的黑色素产生和酪氨酸酶活性，且无明显细胞毒性。此外，这种化学组合的抑制效果在黑色素生成上也超过了单独使用AZ[2]。

体内活性: Azelaic acid 显示出抗动脉粥样硬化效果。它的抗动脉粥样硬化作用与血浆脂质含量的变化无关。补充Azelaic acid 可使CD68巨噬细胞标记水平下降34%（p<0.05）[1]。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: Ethanol : 35 mg/mL (186 mM)
DMSO : 55 mg/mL (292.21 mM)
H2O : 34 mg/mL (180.6 mM)


关键字: Azelaic acid | inhibit | Endogenous Metabolite | Inhibitor

相关产品: Nelarabine | Bractoppin | FIT-039 | Neobavaisoflavone | Beaucage reagent | Dehydroglyasperin D | RdRP-IN-6 | Anisomycin | RNase L-IN-1 | BVDV-IN-1

相关库: Drug Repurposing Compound Library | Human Endogenous Metabolite Library | Marine Natural Product Library | Tobacco Monomer Library | Anti-Cancer Drug Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Anti-Cancer Approved Drug Library | Traditional Chinese Medicine Monomer Library | Miao medicine Compound Library

壬二酸 T0926信息由TargetMol中国为您提供，如您想了解更多关于壬二酸 T0926报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途