番泻苷 A T0966

Product Introduction
Bioactivity


英文名: Sennoside A

描述: Sennoside A (NSC-112929) 是在番泻叶的叶子和豆荚中大量发现的蒽醌苷，抑制 HIV-1 复制。

体外活性: Sennoside A，一种从大黄根茎中分离出的刺激性泻药，通过调节结肠的自发运动产生通便作用。[2] 它对牛血清单胺氧化酶具有轻微的抑制作用，其IC50为17 μM。[1]

体内活性: LD50：小鼠5000 mg/kg（i.g.）；大鼠5000 mg/kg（i.g.）。[3]

存储条件: store at low temperature,keep away from direct sunlightPowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: 5% DMSO+95% Saline : 4.75 mg/mL (5.51 mM, suspension)
H2O : < 1 mg/mL (insoluble or slightly soluble)
DMSO : 95 mg/mL (110.1 mM)
Ethanol : < 1 mg/mL (insoluble or slightly soluble)


关键字: inhibit | Sennoside A | NSC-112929 | Human immunodeficiency virus | Inhibitor | HIV | NSC112929

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相关库: Anti-Tumor Natural Product Library | Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | ReFRAME Related Library | Drug-induced Liver Injury (DILI) Compound Library | Neuronal Signaling Compound Library | Human Metabolite Library | Traditional Chinese Medicine Monomer Library | NO PAINS Compound Library | Anti-Infection Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途