盐酸维拉帕米 T1010

Product Introduction
Bioactivity


英文名: Verapamil hydrochloride

描述: Verapamil hydrochloride (Verapamil HCl) 是一种钙通道阻滞剂，是一种可口服的 P 糖蛋白 (P-gp) 抑制剂，可抑制CYP3A4，用于高血压、心律不齐和心绞痛的研究。

细胞实验: Verapamil is dissolved in DMSO and stored, and then diluted with appropriate media before use[1]. Cells (1×105) are treated with 10 nM Bortezomib and/or 70 μM Verapamil for 16 hours and incubated for another 4 hours with Alamar-Blue. Activity of the mitochondrial dehydrogenase results in conversion of the coloring, which is followed by measurement of the absorption using a spectrophotometer[1].

体外活性: Verapamil可以抗心律失常,减少大鼠心脏氧的消耗,并保存Cx43蛋白.

体内活性: Verapamil和Diltiazem能够基本上抑制重组CES2的水解酶活性(Ki分别为0.25 ± 0.02、3.84 ± 0.99 μM)。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (101.82 mM)
H2O : 24.6 mg/mL (50 mM)


关键字: Ca channels | Verapamil hydrochloride | Verapamil | inhibit | Inhibitor | Verapamil Hydrochloride | pressure | Pgp | ABCB1 | Verapamil hydrochlorid | P-gp | Ca2+ channels | P-glycoprotein | lysosomotropic | Calcium Channel | MDR1 | high | (±)-Verapamil | angina | Palbociclib | Cytochrome P450 | Calcan Hydrochloride | CD243 | Cluster of differentiation 243 | CYP3A4 | Multidrug resistance protein 1 | antiarrhythmic | CYPs | blood

相关产品: Casopitant mesylate | Retrorsine | CYP4A11/CYP4F2-IN-2 | 2-Hydroxy-1-Methoxyaporphine | Eupatorin | SDZ285428 | α-Viniferin | Demethyleneberberine | Corydaline | Amentoflavone

相关库: Anti-Aging Compound Library | Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Anti-COVID-19 Compound Library | Anti-Cancer Drug Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | Inhibitor Library | Anti-Cancer Approved Drug Library | Metabolism Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途