化合物 T10221L T10221L

Product Introduction
Bioactivity


英文名: Abeprazan

描述: Abeprazan (DWP14012) is a potassium-competitive acid blocker and it is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases[1]. Abeprazan inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required.

体外活性: The mechanism of action of Abeprazan is reversibly binding to H+, K+‐ATPase. It unlike that of PPIs, does not require acidic environment for drug activation[1].

体内活性: In various in vivo studies using pylorus-ligated rats, lumen-perfused rat models and heidenhain pouch dog models[1], DWP14012 inhibited acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion was equal to or greater than that of vonoprazan, a previously approved P-CAB.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: DWP-14012 | DWP 14012 | Abeprazan

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途