阿考比芬 T10239

Product Introduction
Bioactivity


英文名: Acolbifene

描述: Acolbifene (SCH 57068) 是一种选择性雌激素受体拮抗剂，对雌二醇诱导的 ERα 和 ERβ 转录活性的 IC50 分别为 2 nM 和 0.4 nM。 Acolbifene 显示出抗癌特性。

体外活性: Acolbifene supports the involvement of the clearance-related receptors in its hypocholesterolemic action without affecting pathways of cholesterol synthesis[2]. Acolbifene inhibits estradiol-stimulated cell proliferation in human breast cancer cancer cells including ZR-75-1, MCF-7 and T-47D[4].

体内活性: In female Sprague-Dawley rats, Acolbifene (2.5 mg/kg; gavage) reduces food intake, strongly decreases cholesterolemia and prevents tumor growth. Acolbifene reduces food intake (16%) and weight gain (45%, mainly fat)[2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 40 mg/mL (87.4 mM)


关键字: SCH-57068 | EM 652 | SCH57068 | Acolbifene | EM652

相关产品: (-)-(S)-Equol | GSK-4716 | Diethylstilbestrol | Bazedoxifene hydrochloride | G36 | MPP hydrochloride | 4-Hydroxyestrone | Isopsoralenoside | Tracheloside | 4-Hydroxytamoxifen

相关库: Drug Repurposing Compound Library | Anti-Cancer Compound Library | Anti-Cancer Drug Library | Clinical Compound Library | Anti-Ovarian Cancer Compound Library | Inhibitor Library | Anti-Cancer Clinical Compound Library | Nuclear Receptor Compound Library | Anti-Cancer Active Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途