化合物AMG 487 T10297L
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
5 mg | 473719-41-4 | ¥1,180.00 | 询底价 |
10 mg | 473719-41-4 | ¥1,680.00 | 询底价 |
1 mL | 473719-41-4 | ¥1,580.00 | 询底价 |
2 mg | 473719-41-4 | ¥898.00 | 询底价 |
1 mg | 473719-41-4 | ¥615.00 | 询底价 |
25 mg | 473719-41-4 | ¥3,550.00 | 询底价 |
50 mg | 473719-41-4 | ¥5,130.00 | 询底价 |
100 mg | 473719-41-4 | ¥7,290.00 | 询底价 |
Product Introduction
Bioactivity
英文名: AMG 487
描述: AMG 487 是可口服的选择性趋化因子受体3拮抗剂,对 I-IP-10、I-ITAC 和 MIG 的 IC50 值分别为 8、15 和 36nM。
体外活性: AMG487 is a small molecular weight antagonist of CXCR3. 66.1 tumor cells were pretreated with AMG487 prior to i.v. injection into immune-competent female mice. Antagonism of CXCR3 on 66.1 tumor cells inhibited experimental lung metastasis, and this antimetastatic activity was compromised in mice depleted of natural killer cells. Systemic administration of AMG487 also inhibited experimental lung metastasis. In contrast to the antimetastatic effect of AMG487, local growth of 66.1 mammary tumors was not affected by receptor antagonism. Murine mammary tumor cells express CXCR3 which facilitates the development of lung metastases.Indicate for the first time that a small molecular weight antagonist of CXCR3 has the potential to inhibit tumor metastasis[2].
体内活性: AMG487, a small molecular weight antagonist. In vivo, systemic CXCR3 antagonism by preventive or curative treatments with AMG487 markedly inhibited the implantation and the growth of human and mouse CRC cells within lung without affecting that in the liver. In addition, we measured increased levels of CXCR3 and ligands expression within lung nodules compared with liver tumours. Activation of CXCR3 receptors by its cognate ligands facilitates the implantation and the progression of CRC cells within lung tissues and that inhibition of this axis decreases pulmonary metastasis of CRC in two murine tumour models[3].
存储条件: store at low temperaturePowder: -20°C for 3 years | In solvent: -80°C for 1 year
溶解度: DMSO : 41 mg/mL (67.93 mM)
关键字: Metastatic | metastasis | inhibit | cancer | CXCL11 | CXC chemokine receptors | CXCL10 | chemokine | AMG487 | AMG-487 | receptor | CXCR3 | CXCR | Inhibitor | Breast | colon | AMG 487
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相关库: Anti-Cancer Compound Library | Cytokine Inhibitor Library | Immuno-Oncology Compound Library | Membrane Protein-targeted Compound Library | GPCR Compound Library | Inhibitor Library | Chemokine Inhibitor Library | Autophagy Compound Library | NO PAINS Compound Library | Bioactive Compound Library
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途