化合物 T10298L2 T10298L2

Product Introduction
Bioactivity


英文名: AMG-548 dihydrochloride (864249-60-5 free base)

描述: AMG-548 dihydrochloride is an orally active and selective p38α inhibitor (Ki: 0.5 nM) and shows slightly selective over p38β (Ki: 36 nM) and >1000 fold selective against p38γ/p38δ. It is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50: 3 nM).

体外活性: AMG-548 dihydrochloride has a modest selectivity against JNK2 (Ki: 39 nM) and JNK3 (Ki: 61 nM). It is also extremely potent in the inhibition of whole blood LPS stimulated TNFa (IC50: 3 nM) and IL1b (IC50: 7 nM) as well as TNFa induced IL-8 (IC50: 0.7 nM) and IL-1b induced IL-6 (IC50: 1.3 nM) in human whole blood [1]. AMG-548 dihydrochloride (10 μM) inhibits the hDvl2 shift [2].

体内活性: AMG-548 dihydrochloride has rat F of 62% and dog F of 47%. The t1/2 is 4.6 hours in rats and 7.3 hours in dogs [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: AMG548 dihydrochloride (864249605 free base) | AMG 548 Dihydrochloride | 864249-60-5 free base | AMG548 Dihydrochloride | AMG-548 Dihydrochloride | AMG 548 | AMG 548 dihydrochloride (864249 60 5 free base) | AMG-548 | AMG548 | 864249-60-5

相关产品: PH-797804 | Dehydrocorydaline chloride | Skatole | p38 MAP Kinase Inhibitor Ⅵ | MAPK13-IN-1 | Trichosanatine | PLK1/p38γ-IN-1 | N-​Feruloyloctopamine | Kobophenol A | Gossypetin

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途