化合物APX-115 free base T10353

Product Introduction
Bioactivity


英文名: APX-115 free base

描述: APX-115 free base (Ewha-18278 free base) 是口服具有活性的、非选择性的 Nox 抑制剂，对 Nox1，Nox2和 Nox4的 Ki 分别为 1.08 μM，0.57 μM 和 0.63 μM。它能够有效预防糖尿病小鼠的肾损伤。

体外活性: In the mouse podocyte cell line, APX-115 free base (5?μM; 60?min) almost completely suppresses high glucose-induced proinflammatory and profibrotic molecule expression. In the kidney, APX-115 free base attenuates Nox gene upregulation and protein expression while improving inflammatory and fibrotic processes [2].

体内活性: APX-115 free base treatment decreases the urinary excretion of albumin and plasma creatinine levels. APX-115 (oral gavage; 60?mg/kg/day; for 12 weeks) significantly improves insulin resistance in diabetic mice.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 245 mg/mL (877.07 mM)


关键字: plasma | APX 115 free base | NOX | Inhibitor | injury | Nox1 | kidney | Ewha18278 | albumin | Ewha 18278 | APX115 free base | Ewha-18278 | insulin | APX115 | Nox3 | resistance | APX-115 | NADPH Oxidase | inhibit | APX-115 free base | APX 115 | creatinine | Nox2

相关产品: Cycloheterophyllin | Isopedicin | Aucuparin | Pisatin | Ketoconazole | Zederone | GKT136901 | Quercetin-3-O-glucose-6''-acetate | gp91ds-tat | Horminone

相关库: Anti-Aging Compound Library | Drug Repurposing Compound Library | Glycometabolism Compound Library | Clinical Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Apoptosis Compound Library | Lipid Metabolism Compound Library | Metabolism Compound Library | Orally Active Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途