化合物 T10379 T10379

Product Introduction
Bioactivity


英文名: Arzoxifene hydrochloride

描述: Arzoxifene hydrochloride is a selective estrogen receptor modulator that is a potent estrogen antagonist in mammary and uterine tissue.

体外活性: Arzoxifene inhibits cell growth as effectively as the antiestrogen tamoxifen. Arzoxifene exerts a statistically significant inhibition of pS2 and progesterone receptor B mRNA expression. A significant agonistic effect is observed in the antitrypsin mRNA expression. In contrast to estradiol and tamoxifen, arzoxifene does not upregulate cathepsin D mRNA and protein expression.

体内活性: Arzoxifene prevents the ovariectomy-induced increase in body weight and serum cholesterol levels of treated rats and lowers them to below sham levels in a dose-dependent manner, with maximum efficacy similar to estrogen or raloxifene. Arzoxifene prevents loss of bone due to ovariectomy with maximal efficacy observed at 0.1-1 mg/kg/day ( ED50: about 0.01 mg/kg). Arzoxifene antagonizes the estrogen-induced elevation in uterine weight down to vehicle-dosed control levels (ED50: 0.03 mg/kg/day).

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: SERM-3 | Arzoxifene hydrochloride | SERM3 | Arzoxifene Hydrochloride

化合物 T10379 T10379信息由TargetMol中国为您提供，如您想了解更多关于化合物 T10379 T10379报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途