化合物 T10427 T10427

Product Introduction
Bioactivity


英文名: AZ505 ditrifluoroacetate

描述: AZ505 ditrifluoroacetate is an effective and selective SMYD2 inhibitor (IC50: 0.12 μM).

体外活性: AZ505 ditrifluoroacetate is highly selective and shows activity at submicromolar concentrations in vitro. The IC50 of AZ505 ditrifluoroacetate for SMYD2 is 0.12 μM, which is >600-fold greater than the IC50s for other histone methyltransferases, such as SMYD3 (IC50>83.3 μM), DOT1L (IC50>83.3 μM) [1]. AZ505 ditrifluoroacetate is nominated for ITC binding study (Kd: 0.5 μM). In contrast, the calculated Kd for the p53 substrate peptide is 3.7 μM. AZ505 ditrifluoroacetate binding to SMYD2 is driven primarily by entropy, which often suggests that binding is mediated by hydrophobic interactions with few specific hydrogen bonds [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 125 mg/mL (155.17 mM)


关键字: AZ 505 | AZ505 ditrifluoroacetate | AZ-505 Ditrifluoroacetate | AZ505 Ditrifluoroacetate | AZ-505 | AZ 505 Ditrifluoroacetate | AZ-505 ditrifluoroacetate | AZ505

相关产品: Tazemetostat hydrobromide | BAY-6035 | (Iso)-MS4322 | EPZ020411 | Valemetostat | MS0124 | GSK467 | EPZ031686 | Pinometostat | UNC0224

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途