化合物 Elimusertib hydrochloride T10468

Product Introduction
Bioactivity


英文名: Elimusertib hydrochloride(1876467-74-1 free base)

描述: Elimusertib hydrochloride(1876467-74-1 free base) (BAY-1895344 hydrochloride) 是一种有效的、可口服的、具有抗肿瘤活性的选择性 ATR 抑制剂。

体外活性: Elimusertib hydrochloride potently inhibits the proliferation of a broad spectrum of human tumor cell lines (median IC50: 78 nM). BAY-1895344 potently suppresses NSC-32065-induced H2AX phosphorylation (IC50: 36 nM) [1].

体内活性: In a variety of xenograft models of ovarian and colorectal cancer, Elimusertib hydrochloride shows potent anti-tumor efficacy in monotherapy and causes complete tumor remission in mantle cell lymphoma models [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 50 mg/mL (121.39 mM)
H2O : 48 mg/mL (116.53 mM)


关键字: BAY1895344 Hydrochloride | BAY 1895344 Hydrochloride | Elimusertib hydrochloride(1876467 74 1 free base) | Elimusertib hydrochloride(1876467-74-1 free base) | Elimusertib hydrochloride(1876467741 free base) | BAY-1895344 Hydrochloride

相关产品: CGK733 | Schisandrin B | Garcinone C | KU60019 | Elimusertib | A011 | CP-466722 | ATR-IN-21 | Tuvusertib | Gartisertib

相关库: Drug Repurposing Compound Library | Anti-Cancer Drug Library | Neuronal Differentiation Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Clinical Compound Library | Kinase Inhibitor Library | Anti-Cancer Active Compound Library | DNA Damage & Repair Compound Library | NO PAINS Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途