化合物 T10594 T10594

Product Introduction
Bioactivity


英文名: bpV(phen)

描述: bpV(phen) is a potent protein tyrosine phosphatase (PTP) and PTEN inhibitor (IC50s: 343 nM, 920 nM, and 38 nM for PTP-β, PTP-1B, and PTEN).

体外活性: bpV(phen) (5 μM; 24.5 hours; H9c2 cells) treatment causes a further decrease of cell viability in H/R-injured H9c2 cells and increases the apoptosis of H/R-injured H9c2 cells. bpV(phen) (5 μM; 24.5 hours; H9c2 cellfs) treatment significantly promotes the accumulation of cytoplasmic Cytochrome C in H/R-injured H9c2 cells. After stimulation of bpV(phen), PTEN-induced putative kinase protein 1 (PINK1)/Parkin-mediated mitophagy is inhibited [1].

体内活性: bpV(phen) (5 mg/kg; i.p.; daily; for 38 days; male BALB/c nude (nu/nu) athymic mice) treatment causes a significant reduction in average tumor volume [1].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: bpV(phen)

相关产品: SF1670 | Ginkgolic acid C17:1 | Oroxin B | Valinomycin | VO-Ohpic trihydrate | Afzelin | BpV(HOpic) | Cucurbitacin B

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途