化合物 T10600 T10600
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 1622262-74-1 | ¥17,200.00 | 询底价 |
50 mg | 1622262-74-1 | ¥22,800.00 | 询底价 |
100 mg | 1622262-74-1 | ¥29,500.00 | 询底价 |
Product Introduction
Bioactivity
英文名: BRCA1-IN-1
描述: BRCA1-IN-1 is a novel small-molecule-like inhibitor of BRCA1 (IC50: 0.53 μM; Ki: 0.71 μM).
体外活性: BRCA1 is a BRCT domain-containing, a tumor-suppressing protein expressed in the cells of breast and other tissues. By targeting the (BRCT)2 domain, BRCA1-IN-1 (Compound 15a) inhibits BRCA1 activities in tumor cells, sensitizes these cells to ionizing radiation-induced apoptosis, and shows the synergistic inhibitory effect when used in combination with Olapari and Etoposide. BRCA1-IN-1 can effectively inhibit HR activity by binding to BRCA1(BRCT)2, and functionally mimic the genetic knockdown of BRCA1. BRCA1-IN-1 is useful in targeting BRCA1/PARP-related pathways involved in DNA damage and repair response, for cancer therapy.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: BRCA1 IN 1 | BRCA1-IN-1 | BRCA-1-IN-1 | BRCA1IN1
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途