溴虫氟苯双酰胺 T10618

Product Introduction
Bioactivity


英文名: Broflanilide

描述: Broflanilide 是昆虫抗狄氏剂 GABA 受体拮抗剂，可代谢为 Desmethyl-Broflanilide，抑制斜纹夜蛾 RDL GABAR，IC50值为 1.3 nM。

体外活性: Broflanilide 作为一种杀虫剂，其代谢产物为desmethyl-broflanilide。Desmethyl-broflanilide对人类GABAA α1β2γ2受体、哺乳动物GABAA α1β3γ2受体以及人类甘氨酸受体(GlyR) α1β的抑制活性较弱，其IC50均大于3 μM。此外，Broflanilide 对GlyR α1-A288Gβ和GlyR α1-A288G的抑制作用较为弱，其IC50分别为0.706 μM和0.149 μM。

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 225 mg/mL (339.22 mM)


关键字: inhibit | GABA Receptor | Gamma-aminobutyric acid Receptor | Broflanilide | γ-Aminobutyric acid Receptor | Inhibitor

相关产品: (-)-Bicuculline methochloride | RO 4938581 | Flumazenil | Tramiprosate | (E)-GABAB receptor antagonist 1 | Homocarnosine acetate | Basmisanil | ONO-8590580 | AZD-6280 | β-Alanine

相关库: Ion Channel Inhibitor Library | Anti-Neurodegenerative Disease Compound Library | Neurotransmitter Receptor Compound Library | Anti-Parkinson's Disease Compound Library | Anti-Cancer Compound Library | Membrane Protein-targeted Compound Library | Bioactive Compounds Library Max | Neuronal Signaling Compound Library | Inhibitor Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途