酒石酸去甲肾上腺素 T1064

Product Introduction
Bioactivity


英文名: Norepinephrine bitartrate monohydrate

描述: Norepinephrine bitartrate monohydrate (Levophed) 是一种β1-选择性的肾上腺素能受体激动剂，EC50为 5.37 μM。

细胞实验: Norepinephrine (NE)is dissolved in DMSO and stored, and then diluted with appropriate media before use[2]. Subcutaneous preadipocytes derived from a 38-year old non-diabetic female donor are immortalized with TERT and HPV E6/E7. For the current studies, a stable diploid clone (referred to as clone B) with consistent differentiation capacity is isolated by ring cloning. Cells are grown in preadipocyte PGM2 media. Once cells are confluent, differentiation is induced by incubation in differentiation media consisting of dexamethasone, IBMX, indomethacin, and additional insulin. Cells are differentiated for 10 days. Prior to treatment, media is replaced with PGM2 media for one day and then switched to serum-free media overnight for treatments. Adipocytes are treated for 6 hours with vehicle, Norepinephrine (NE, 10 μM), CGP (10 nM), or Norepinephrine (NE) and CGP[2].

体外活性: Noradrenaline 通过调节感知区域诱发活动的增益，特别是在感觉区域。除了强调其短期影响的数据外，Noradrenaline 还促进长期突触可塑性。Noradrenaline 传递“对环境中产生强烈违反顶层预期的感官信息的粗略变化”的信号，并通过增强“自下而上”的信息处理，降低与相关“自上而下”的预期。[1] Noradrenaline 调节动力和能量，并对包括学习、记忆、睡眠、唤醒和适应在内的特定过程进行精细调节。Noradrenaline 系统密切涉及一系列心理过程。这些过程一旦受到干扰，就可能导致可归类的精神疾病的表现。Noradrenaline 似乎涉及包括警觉性、认知、学习和睡眠调节在内的一系列心理过程，并且还在调节应对可能引发或加剧抑郁症状的压力反应中发挥作用。Noradrenaline 在这条路径上的缺陷可能会降低注意力，影响工作记忆，导致精神运动迟缓，从而产生冷漠和抑郁，而这一途径Noradrenaline 的增加有望缓解注意力不集中、冷漠和抑郁。[2] Noradrenaline 的效应复杂，取决于实验条件（延髓和骨髓制备）和物种（大鼠或小鼠）。外源性Noradrenaline 主要是促进或主要抑制新生RRG，具有α1促进效应和α2抑制效应的混合体。[3]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 31.9 mg/mL (100 mM)
DMSO : 31.9 mg/mL (100 mM)


关键字: Norepinephrine bitartrate monohydrate | Noradrenaline bitartrate Monohydrate | Autophagy | Levarterenol bitartrate | Norepinephrine bitartrate | Beta Receptor | L-Noradrenaline bitartrate | Inhibitor | inhibit | Norepinephrine bitartrate Monohydrate | Adrenergic Receptor | Endogenous Metabolite | Noradrenaline bitartrate

相关产品: Hyodeoxycholic acid | γ-Glu-Phe TFA(7432-24-8 free base) | N-acetyl-D-Lactosamine | Trigonelline | 3-Methyl-2-oxobutanoic acid | Bilirubin | alpha-Cyperone | Dimethyl sulfone | Menaquinone-4 | Lipoic acid

相关库: FDA-Approved Drug Library | Anti-Neurodegenerative Disease Compound Library | Drug Repurposing Compound Library | Toxic Compound Library | Anti-Cancer Drug Library | Coagulation and Anticoagulation Compound Library | Membrane Protein-targeted Compound Library | Anti-Cancer Clinical Compound Library | GPCR Compound Library | Anti-Cancer Approved Drug Library

酒石酸去甲肾上腺素 T1064信息由TargetMol中国为您提供，如您想了解更多关于酒石酸去甲肾上腺素 T1064报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途