化合物CB-6644 T10693

Product Introduction
Bioactivity


英文名: CB-6644

描述: CB-6644 是 RUVBL1/2的选择性复合体抑制剂，能够抑制 RUVBL1/2 的 ATP 酶活性(IC50:15 nM)。它具有抗癌作用。

体外活性: CB-6644 (20 μM) interacts with the RUVBL1/2 complex in Ramos cells. CB-6644 (0.001-10 μM; 72 hours) potently kills 123 cell lines (EC50: 41 to 785 nM).

体内活性: CB-6644 (150 mg/kg, p.o., 30 days of treatment for SCID-beige mice bearing RPMI8226 xenograft models, 10 days of treatment for SCID-beige mice bearing Ramos xenograft models) has antitumor activity in xenograft tumor models. The tumor growth inhibitions (TGIs) are 68 and 81%, respectively in Ramos xenograft models and RPMI8226 xenograft models.

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 1mg/ml


关键字: CB6644 | CB-6644 | Inhibitor | CB 6644 | inhibit

相关库: Anti-Cancer Compound Library | Bioactive Compounds Library Max | Inhibitor Library | Anti-Cancer Active Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途