化合物 T10695 T10695

Product Introduction
Bioactivity


英文名: CB1151

描述: CB1151 is a 20-epi analogue of 1,25 dihydroxyvitamin D3 with anti-tumor effects. It inhibits MCF-7 cell growth (IC50: 0.82 nM).

体外活性: CB1151 (0-100 nM; 5 days) inhibits MCF-7 cells growth, this cell proliferation is accessed by [3H]-thymidine incorporation (IC50: 0.82 nM). CB1151 (0-100 nM; 40 hours) exhibits activation of the IP9-type VD response element (EC50: 1.2 nM), the activation of IP9-type VD response elements shows a good correlation with inhibition of proliferation than the activation of DR3-type elements (EC50: 3.2nM) in MCF-7 cells transfected with the CAT reporter [1]. CB1151 shows a functional dissociation constant (Kdf) value of 3.6 nM. The ligand concentration that provides 50% of the protease-resistant VDR fragment is defined by Kdf [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: CB1151 | CB 1151 | CB-1151

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途