化合物 T10699L2 T10699L2

Product Introduction
Bioactivity


英文名: CBB1007 trihydrochloride (1379573-92-8 free base)

描述: CBB1007 trihydrochloride is a selective, reversible, and substrate competitive LSD1 inhibitor (IC50: 5.27 μM for hLSD1).

体外活性: CBB1007 efficiently can block LSD1-mediated demethylation of H3K4Me2 and H3K4Me (IC50 ≤ 5 μM) with no effect on H3K4Me3 and H3K9Me2, and LSD2 and JARID1A activities. Increases H3K4Me2 and H3K4Me contents (IC50 ≤ 5 μM), and causes activation of epigenetically suppressed CHRM4/M4-ArchR and SCN3A genes in F9 cells (IC50 ≤ 3.74 μM).

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 54 mg/mL (83.85 mM)


关键字: 1379573-92-8 | CBB 1007 Trihydrochloride | CBB-1007 | CBB1007 | CBB-1007 Trihydrochloride | CBB1007 trihydrochloride (1379573 92 8 free base) | CBB1007 Trihydrochloride | 1379573-92-8 free base | CBB-1007 trihydrochloride (1379573-92-8 free base) | CBB 1007 | CBB1007 trihydrochloride (1379573928 free base)

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途