化合物CGS 15435 T10783

Product Introduction
Bioactivity


英文名: CGS 15435

描述: CGS 15435是一种有效的血栓素(TxA2)合成酶抑制剂(IC50: 1 nM)。CGS 15435作用于 PGI2合成酶、环氧合酶和脂合酶比作用于血栓素合成酶选择性低得多。

体外活性: CGS 15435 inhibited the formation of PGE2 (IC50:1200 μM), PGI2 synthetase (IC50:90 μM) and 5-lipoxygenase (IC50:60 μM).[1]

体内活性: The effect of CGS 15435 was long lasting, as the increase of plasma TxB2 levels was prevented even 24 hours after the administration of CGS 15435. CGS 15435 inhibited the formation of TxB2 significantly at 4, 6, 12 and 24 h after administration. Administration of CGS 15435 0.25 or 24 h before arachidonic acid (AA) did not increase TxB2 in surviving animals (4/4 and 5/6, respectively). The final TxB2 level in CGS15435A(pretreatment for 0.25 and 24 h) groups was significantly lower than that in arachidonic acid (AA) and daxibon (pretreatment for 2 h) groups.[1]

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: DMSO : 3.57 mg/mL (10 mM)


关键字: CGS-15435 | CGS 15435 | CGS15435

相关产品: Bezafibrate | Oleoylethanolamide | Astaxanthin | 2,3-Butanediol | Licarin B | MSDC-0602K | GW7647 | T0070907 | RGX-202 | Bocidelpar

相关库: Bioactive Compounds Library Max | Inhibitor Library | Nuclear Receptor Compound Library | DNA Damage & Repair Compound Library | Bioactive Compound Library

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途