化合物 T10838 T10838

Product Introduction
Bioactivity


英文名: Closthioamide

描述: Closthioamide is a potent inhibitor of bacterial DNA gyrase and highly active against MRSA, Ec, VRE, and Mv (MICs: 0.58 μM, 9.00 μM, 0.58 μM and 72.03 μM).

体外活性: Closthioamide is isolated from the strictly anaerobic bacterium Clostridium cellulolyticum, and belongs to a new class of natural products [1]. Closthioamide is highly active against a pathogenic, methicillin-resistant Staphylococcus aureus (MRSA) strain with a minimum inhibitory concentration (MIC) of 0.4 μg/mL-1 (0.58 μM). Closthioamide is even active against vancomycin-resistant Enterococcus faecalis (VRE) with the same low MIC value and is thus significantly more potent against these bacteria than ciprofloxacin, the standard drug used against VRE, with remarkable strain selectivity. Closthioamide shows moderate antiproliferative and cytotoxic effects [2].

存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year

关键字: Closthioamide

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注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途