化合物 T10968 T10968
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
25 mg | 615538-51-7 | ¥10,600.00 | 询底价 |
50 mg | 615538-51-7 | ¥13,800.00 | 询底价 |
100 mg | 615538-51-7 | ¥17,500.00 | 询底价 |
Product Introduction
Bioactivity
英文名: DC0-NH2
描述: The cytotoxicity of DC0-NH2 is 1000 times that of commonly used anti-cancer drugs (such as doxorubicin). It is the effect part of ADC. It is a simplified simulation of DC1 and has better stability. DC0-NH2 can bind to the small groove of DNA, and then adenine residue is alkylated by its propabenzindole (CBI) component.
体外活性: DC0-NH2 (0-3 nM; 72 hours), in the vitality test of breast cancer cell lines, has a high anti-proliferative effect on Ramos, Namalwa and HL60 / s cells, inhibits the proliferation of Namalwa and HL60 / s cells The IC50 values were 7 pM and 5 pM, respectively, and the inhibition range of COLO205 cells was within 100 pM.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: DC0-NH2 | DC-0-NH2 | DC0NH2 | DC0 NH2
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途