化合物 T10988 T10988

Product Introduction
Bioactivity


英文名: Degarelix

描述: Degarelix is a competitive and reversible gonadotropin-releasing hormone receptor (GnRHR) antagonist.

体外活性: Degarelix directly acts on the pituitary receptors to luteinizing hormone-releasing hormone (LHRH), preventing the effect of endogenous LHRH. The use of degarelix eliminates the undesirable surge of initial gonadotropin and testosterone levels produced by LHRH agonists. With the exception of PC-3 cells, Degarelix treatment reduces the cell viability of all prostate cell lines (WPE1-NA22, WPMY-1, BPH-1 cells, VCaP cells). GnRH antagonist degarelix has a direct effect on the growth of prostate cells through apoptosis.

体内活性: In a single subcutaneous injection of 0.3 to 10 μg/kg in rats, degarelix produced a dose-dependent inhibition of the pituitary-gonad axis as revealed by the decrease in plasma luteinizing hormone (LH) and testosterone levels. The duration of LH inhibition increased with increasing dose: in rats, after subcutaneous injection of digarelix 12.5, 50 or 200 μg/kg, the significant inhibition of LH lasted 1, 2 and 7 days, respectively [ 3]. Degarelix is stable when incubated in microsomes and liver cells cryopreserved in animal liver tissue.

存储条件: keep away from moisturePowder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度: H2O : 25 mg/mL (15.32 mM)
DMSO : 10 mg/mL (6.13 mM)


关键字: Degarelix

相关产品: LGnRH-III, lamprey acetate(147859-97-0 free base) | Degarelix acetate(214766-78-6 free base) | Deslorelin acetate(57773-65-6 free base) | Lecirelin acetate(61012-19-9 free base) | Buserelin Acetate (57982-77-1 free base) | GnRH-R antagonist 1 | (R)-Elagolix | Linzagolix | Cetrorelix Acetate | Goserelin acetate

化合物 T10988 T10988信息由TargetMol中国为您提供，如您想了解更多关于化合物 T10988 T10988报价、型号、参数等信息，欢迎来电或留言咨询。

注：该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案，不可用于临床诊断或治疗等相关用途