黑僵菌素 B T11009
品牌 | 厂商性质 | 产地 | 货期 |
---|---|---|---|
TargetMol | 生产商 | 美国 | 现货 |
性能特点
生化试剂,可用于动物细胞实验
规格 | CAS号 | 价格 | 操作 |
---|---|---|---|
1 mg | 2503-26-6 | ¥8,310.00 | 询底价 |
5 mg | 2503-26-6 | ¥29,700.00 | 询底价 |
Product Introduction
Bioactivity
英文名: Destruxin B
描述: Destruxin B is a cyclic peptide with insecticidal and anticancer activity isolated from the insect pathogenic fungus Metarhizium isopliae. Destruxin B induces apoptosis of human non-small cell lung cancer cells through the Bcl-2 family-dependent mitochondrial pathway. Destruxin B through caspase-mediated apoptosis can significantly activate caspase-3 in vitro and in vivo, reducing the proliferation of tumor cells.
体外活性: Destruxin B (1-30 μM; mitochondrial blocking caspase cascade activation inhibits cell proliferation of Destruxin B (1-30 μM; 48 hours) H1299 cells and A549 cells with IC50 of 4.1 μM and 4.9 μM, respectively. Destruxin B (1.25-20.00μM; 48 hours) plays an important role in the induced apoptotic cell death of A549 cells. The treatment of 12 and 24 hours significantly increases the level of A549 cell promoter protein PUMA and reduces the resistance to degradation in an alternating manner of concentration and time The level of protein Mcl-1. Destruxin B (10 or 20 μm; 72 hours) treatment significantly reduced the survival ability of HT-29 human colorectal cancer with time and dose reduction.
体内活性: Destruxin B (DB) (injection; 0.5-15 mg/kg/d for 6 weeks) reduces tumor growth in a time- and dose-dependent manner.
存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year
关键字: Destruxin B
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注:该产品未在中华人民共和国食品药品监督管理部门申请医疗器械注册和备案,不可用于临床诊断或治疗等相关用途